N-Acetyl-l-Cysteine Ameliorations RenalFunction Early After Renal Ischemia and Reperfusion; it is not Protective over a LongTerm under a High-Sodium Diet in Rats

Objective To evaluate the early and late effects of N-acetyl-l-cysteine (NAC) treatment on renal ischemia reperfusion (I/R) insult in adult Wistar rats influenced by chronic high sodium (HS) intake. Methods Adult male (8 weeks age) received an HS (8.0% NaCl) or normal (NS; 1.3% diet NAC (600 mg/L) drinking water water. At 11 age, underwent a I/R procedure. They followed for 10 after I/R, at 1st, 2nd, 4th, 10th weeks, which tail blood pressure (tBP) function were evaluated. And renin gene expression was evaluated week I/R. Results During study, it observed that tBP remained consistently higher HS-I/R+water group compared to NS-I/R+water group. However, following (1st, 4th weeks), lower HS-I/R+NAC than In serum creatinine levels both NS-I/R+NAC groups groups. Conversely, clearance HS-I/R+ 2nd Additionally, urinary protein It also resulted increased Conclusions After animals given HS, initially effective lowering increasing clearance. these positive did not persist over long term, resulting decreased kidney pressure. Furthermore, renin-angiotensin-aldosterone system intake, benefits NS less those diet. Thus, provides temporary protection only stages insult.